Watch Grey's Anatomy S04E16 streaming

Season 4, Episode 16

A couple undergoes surgery. Derek and Meredith's clinical trial gets a second shot from a new patient. Izzie helps Alex. McSteamy hooks up with someone.

Year started: 2005
Country: US
IMDB rating: 7.6
Creators: Shonda Rhimes
Categories: Drama Romance
Stars: Ellen Pompeo Chandra Wilson James Pickens, Jr. Justin Chambers Sara Ramirez Patrick Dempsey Kevin McKidd Sandra Oh Jessica Capshaw Jesse Williams Sarah Drew Eric Dane Camilla Luddington Katherine Heigl Chyler Leigh Jerrika Hinton T.R. Knight Jason George Caterina Scorsone Kelly McCreary Isaiah Washington Kim Raver Kate Walsh Giacomo Gianniotti Gaius Charles Martin Henderson Tessa Ferrer Brooke Smith

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